The transient receptor potential channel TRPA1: from gene to pathophysiology

  title={The transient receptor potential channel TRPA1: from gene to pathophysiology},
  author={Bernd Nilius and Giovanni Appendino and Grzegorz Owsianik},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the large TRP family of ion channels, and functions as a Ca2+ permeable non-selective cation channel in many different cell processes, ranging from sensory to homeostatic tasks. TRPA1 is highly conserved across the animal kingdom. The only mammalian TRPA subfamily member, TRPA1, is widely expressed in neuronal (e.g. sensory dorsal root and trigeminal ganglia neurons)- and in non-neuronal cells (e.g. epithelial cells… CONTINUE READING
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TRPA 1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT3

  • K Shintaku, K Uchida, +5 authors M Tominaga
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The involvement of TRPA 1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice

  • M Sisignano, CK Park, +16 authors C Brenneis
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