The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs

@article{Chang2016TheTE,
  title={The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs},
  author={Fei Chang and Rui Fang and M. Wang and X. Zhao and W. Chang and Zaihu Zhang and N. Li and Q. Meng},
  journal={Transgenic Research},
  year={2016},
  volume={26},
  pages={25-36}
}
Follistatin (FST), which was first found in the follicles of cattle and pigs, has been shown to be an essential regulator for muscle development. [...] Key Result The transgenic pigs exhibited an increased proportion of skeletal muscle and a reduced proportion of body fat that were similar to those reported in myostatin-null cattle. The lean percentage of lean meat was significantly higher in the F1 generation of TG pigs (72.95 ± 1.0 %) than in WT pigs (69.18 ± 0.97 %) (N = 16, P < 0.05).Expand
Methylation Status of the Follistatin Gene at Different Development Stages of Japanese Flounder (Paralichthys olivaceus)
...
1
2
...

References

SHOWING 1-10 OF 45 REFERENCES
Overexpression of follistatin in trout stimulates increased muscling.
Regulation of muscle mass by follistatin and activins.
Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin.
Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates
Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle.
Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects.
Multiple defects and perinatal death in mice deficient in follistatin
Double muscling in cattle due to mutations in the myostatin gene.
  • A. Mcpherron, S. J. Lee
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
Myostatin and its implications on animal breeding: a review.
...
1
2
3
4
5
...