The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes.

@article{Bode2000TheTT,
  title={The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes.},
  author={J{\"u}rgen Bode and Thomas Schlake and Metin Iber and Dirk Sch{\"u}beler and Jost Seibler and Eugene Snezhkov and L Nikolaev},
  journal={Biological chemistry},
  year={2000},
  volume={381 9-10},
  pages={801-13}
}
Classical techniques for gene transfer into mammalian cells involve tedious screening procedures to identify transgenic clones or animals with the appropriate level and stability of expression or with the correct developmental patterns. These first generation technologies are clearly inadequate for complex genetic strategies by which gene regulation can be studied in its entire complexity. While site-specific insertions can principally be achieved by homologous recombination or by adapting the… CONTINUE READING

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