The transferrin receptor.

@article{Testa1993TheTR,
  title={The transferrin receptor.},
  author={Ugo Testa and Elvira Pelosi and Cesare Peschle},
  journal={Critical reviews in oncogenesis},
  year={1993},
  volume={4 3},
  pages={
          241-76
        }
}
Transferrin receptor (TfR) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin, the major iron-carrier protein. This receptor plays a key role in the control of cell proliferation because iron is essential for sustaining ribonucleotide reductase activity, and is the only enzyme that catalyzes the conversion of ribonucleotides to deoxyribonucleotides. Furthermore, TfR is overexpressed in several tumors. The synthesis of the receptor is… CONTINUE READING

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