The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus.

@article{Wang2011TheTO,
  title={The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirus.},
  author={C K Wang and Leslie W. Chan and Russell N. Johnson and David S. H. Chu and Julie Shi and Joan G. Schellinger and Andr{\'e} Lieber and Suzie H Pun},
  journal={Biomaterials},
  year={2011},
  volume={32 35},
  pages={9536-45}
}
Adenoviral (AdV) gene vectors offer efficient nucleic acid transfer into both dividing and non-dividing cells. However issues such as vector immunogenicity, toxicity and restricted transduction to receptor-expressing cells have prevented broad clinical translation of these constructs. To address this issue, engineered AdV have been prepared by both genetic and chemical manipulation. In this work, a polymer-coated Ad5 formulation is optimized by evaluating a series of N-(2-hydroxypropyl… CONTINUE READING
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