The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells.

@article{Dorsam2004TheTO,
  title={The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells.},
  author={Sheri Tinnell Dorsam and Christina M Ferrell and Glenn Paul Dorsam and Mika Kakefuda Derynck and Ulka Vijapurkar and Daniel B Khodabakhsh and Bonnie Pau and Hillary Bernstein and Christopher M. Haqq and Corey Largman and Hugh Jeffrey Lawrence},
  journal={Blood},
  year={2004},
  volume={103 5},
  pages={1676-84}
}
Hematopoietic defects in HOXA9(-/-) mice demonstrate a key role for this homeoprotein in blood cell development. Conversely, enforced HOXA9 expression is leukemogenic in mice, and HOXA9 is frequently activated in human acute myeloid leukemia (AML). Although HOXA9 is thought to function as a transcription factor, few downstream targets have been identified. We searched for early HOXA9 target genes by using a transient overexpression strategy in 3 hematopoietic cell lines (2 myeloid, 1 lymphoid… CONTINUE READING

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