The transcriptional regulatory protein, YB-1, promotes single-stranded regions in the DRA promoter.

@article{Macdonald1995TheTR,
  title={The transcriptional regulatory protein, YB-1, promotes single-stranded regions in the DRA promoter.},
  author={Gene H Macdonald and Yoshie Itoh-Lindstrom and Jenny P-Y Ting},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 8},
  pages={3527-33}
}
YB-1 is a member of a newly defined family of DNA- and RNA-binding proteins, the Y box factors. These proteins have been shown to affect gene expression at both the transcriptional and translational levels. Recently, we showed that YB-1 represses interferon-gamma-induced transcription of class II human major histocompatibility (MHC) genes (1). Studies in this report characterize the DNA binding properties of purified, recombinant YB-1 on the MHC class II DRA promoter. The generation of YB-1… CONTINUE READING

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