The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

@article{Yang2011TheTR,
  title={The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets},
  author={Cliff Y. Yang and John Adam Best and Jamie Knell and Edward Yang and Alison D. Sheridan and Adam K Jesionek and Haiyan S Li and Richard R. Rivera and K. Lind and Louise M D'Cruz and Stephanie S Watowich and Cornelis Murre and Ananda W Goldrath},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={1221-1229}
}
During infection, naive CD8+ T cells differentiate into effector cells, which are armed to eliminate pathogens, and memory cells, which are poised to protect against reinfection. The transcriptional program that regulates terminal differentiation into short-lived effector-memory versus long-lived memory cells is not clearly defined. Through the use of mice expressing reporters for the DNA-binding inhibitors Id2 and Id3, we identified Id3hi precursors of long-lived memory cells before the peak… CONTINUE READING
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