The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer.

@article{Ribas2010TheTR,
  title={The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer.},
  author={Judit Ribas and Shawn E Lupold},
  journal={Cell cycle},
  year={2010},
  volume={9 5},
  pages={923-9}
}
MicroRNAs (miRNAs) are a natural part of the most recently discovered and global regulatory pathway known as RNA interference. Functional studies have shown how specific miRNAs can function as tumor suppressors or oncogenes and, correspondingly, deregulated miRNA profiles have been observed in prostate and other cancers. However, the upstream pathways which regulate miRNA expression are only currently being uncovered. The Androgen Receptor (AR) is a nuclear hormone receptor and transcription… CONTINUE READING

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