The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.

@article{Wilson2009TheTP,
  title={The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.},
  author={Nicola K. Wilson and Diego Miranda-Saavedra and Sarah Kinston and Nicolas Bonadies and Samuel D. Foster and Fernando J. Calero-Nieto and Mark A Dawson and Ian John Donaldson and St{\'e}phanie Dumon and Jonathan Frampton and Rekin's Janky and Xiao-Hong Sun and Sarah A. Teichmann and Andrew J. Bannister and Berthold G{\"o}ttgens},
  journal={Blood},
  year={2009},
  volume={113 22},
  pages={5456-65}
}
The basic helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of hematopoietic stem cells (HSCs). However, because few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. In this study, we have used ChIP-Seq technology (coupling chromatin immunoprecipitation with deep sequencing) to generate a genome-wide catalog of Scl-binding events in a stem/progenitor cell line, followed by validation using… CONTINUE READING

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