The transcriptional landscape of age in human peripheral blood

  title={The transcriptional landscape of age in human peripheral blood},
  author={Marjolein J. Peters and Roby Joehanes and Luke C Pilling and Claudia Schurmann and Karen N. Conneely and Joseph E. Powell and Eva Reinmaa and George L. Sutphin and Alexandra Zhernakova and Katharina Schramm and Yana A. Wilson and Sayuko Kobes and Taru Tukiainen and Yolande F M Ramos and Harald H. H. G{\"o}ring and Myriam Fornage and Yongmei Liu and Sina A Gharib and Barbara E. Stranger and Philip L De Jager and Abraham Aviv and Daniel A. Levy and Joanne M. Murabito and Peter J. Munson and Tianxiao Huan and Albert Hofman and Andr{\'e} G. Uitterlinden and Fernando Rivadeneira and Jeroen van Rooij and Lisette Stolk and Linda Broer and Michael M. P. J. Verbiest and Mila Jhamai and Pascal A Arp and Andres Metspalu and Liina Tserel and Lili Milani and Nilesh J. Samani and P{\"a}rt Peterson and Silva Kasela and Veryan Codd and Annette Peters and Cavin K Ward-Caviness and Christian Herder and Melanie Waldenberger and Michael Roden and Paula Singmann and Sonja Zeilinger and Thomas Illig and Georg Homuth and Hans J{\"o}rgen Grabe and Henry V{\"o}lzke and Leif Steil and Thomas David Kocher and Anna Murray and David Melzer and Hanieh Yaghootkar and Stefania Bandinelli and E. K. Moses and Jack W. Kent and Joanne E. Curran and Matthew P. Johnson and Sarah Williams-Blangero and Harm-Jan Westra and Allan F. McRae and Jennifer A. Smith and Sharon L. R. Kardia and Iiris Hovatta and Markus Perola and Samuli Ripatti and Veikko V Salomaa and Anjali K. Henders and Nicholas G. Martin and Alicia K. Smith and Divya Mehta and Elisabeth B. Binder and Karin Maria Nylocks and Elizabeth M Kennedy and Torsten Klengel and Jingzhong Ding and Astrid M. Suchy-Dicey and Daniel A. Enquobahrie and Jennifer A Brody and Jerome I. Rotter and Yii-Der I. Chen and Jeanine J. Houwing-Duistermaat and Margreet Kloppenburg and Pieternella E Slagboom and Quinta Helmer and Wouter J den Hollander and Shannon Bean and Towfique Raj and Noman Bakhshi and Qiao Ping Wang and Lisa J. Oyston and Bruce M. Psaty and Russell P Tracy and Grant W. Montgomery and Stephen T. Turner and John Blangero and Ingrid Meulenbelt and Kerry J. Ressler and Jian Yang and Lude Franke and Johannes Kettunen and Peter M. Visscher and G. Gregory Neely and Ron Korstanje and Robert L Hanson and Holger Prokisch and Luigi Ferrucci and T{\"o}nu Esko and Alexander Teumer and Joyce B. J. van Meurs and Andrew D. Johnson and Michael A. Nalls and Dena G. Hernandez and Mark R Cookson and Raphael J. Gibbs and John S. Hardy and Adaikalavan Ramasamy and Alan B. Zonderman and Allissa Dillman and Bryan G Traynor and Colin B. Smith and Dan L. Longo and Daniah Trabzuni and Juan Troncoso and Marcel van der Brug and Michael E. Weale and Richard O'Brien and Robert E. Johnson and Robert Walker and Ronald H. Zielke and Sampath Arepalli and Mina Ryten and Andrew Singleton},
  booktitle={Nature communications},
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for… CONTINUE READING