The transcriptional interactome: gene expression in 3D.

@article{Schoenfelder2010TheTI,
  title={The transcriptional interactome: gene expression in 3D.},
  author={Stefan Schoenfelder and Ieuan Clay and Peter Fraser},
  journal={Current opinion in genetics & development},
  year={2010},
  volume={20 2},
  pages={
          127-33
        }
}
Transcription in the eukaryotic nucleus has long been thought of as conforming to a model in which RNA polymerase complexes are recruited to and track along isolated templates. However, a more dynamic role for chromatin in transcriptional regulation is materializing: enhancer elements interact with promoters forming loops that often bridge considerable distances and genomic loci, even located on different chromosomes, undergo chromosomal associations. These associations amass to form an… CONTINUE READING
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