The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

@article{Duteil2010TheTC,
  title={The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.},
  author={Delphine Duteil and C{\'e}line Chambon and Faisal HH Ali and Rocco Malivindi and Joffrey Zoll and Shigeaki Kato and Bernard G{\'e}ny and Pierre Chambon and Daniel Metzger},
  journal={Cell metabolism},
  year={2010},
  volume={12 5},
  pages={496-508}
}
The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm)⁻(/)⁻ mice in which TIF2 was selectively ablated in skeletal muscle myofibers at adulthood. We found that increased mitochondrial uncoupling in skeletal muscle myocytes protected these mice from decreased muscle oxidative capacities induced by… CONTINUE READING
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