The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes.

@article{Biddick2008TheTC,
  title={The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes.},
  author={Rhiannon Biddick and G Lynn Law and Kevin Khaw Beng Chin and Elton T. Young},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 48},
  pages={
          33101-9
        }
}
The paradigm of activation via ordered recruitment has evolved into a complicated picture as the influence of coactivators and chromatin structures on gene regulation becomes understood. We present here a comprehensive study of many elements of activation of ADH2 and FBP1, two glucose-regulated genes. We identify SWI/SNF as the major chromatin-remodeling complex at these genes, whereas SAGA (Spt-Ada-Gcn5-acetyltransferase complex) is required for stable recruitment of other coactivators… CONTINUE READING

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