The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.

@article{Gusterson2003TheTC,
  title={The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity.},
  author={Rosalind J Gusterson and Elen P I Jazrawi and Ian M. Adcock and D. S. Latchman},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 9},
  pages={
          6838-47
        }
}
The CBP and p300 proteins are transcriptional co-activators that are involved in a variety of transcriptional pathways in development and in response to specific signaling pathways. We have previously demonstrated that the ability of both these factors to stimulate transcription is greatly enhanced by treatment of cardiac cells with the hypertrophic agent phenylephrine (PE). Here, we show that inhibition of either CBP or p300 with antisense or dominant negative mutant constructs inhibits PE… CONTINUE READING
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