The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.

@article{Relaix2003TheTA,
  title={The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.},
  author={Fr{\'e}d{\'e}ric Relaix and Mariarosa Polimeni and Didier Rocancourt and Carola Ponzetto and Beat W. Sch{\"a}fer and M. Buckingham},
  journal={Genes & development},
  year={2003},
  volume={17 23},
  pages={2950-65}
}
Pax3 is a key transcription factor implicated in development and human disease. To dissect the role of Pax3 in myogenesis and establish whether it is a repressor or activator, we generated loss- and gain-of-function alleles by targeting an nLacZ reporter and a sequence encoding the oncogenic fusion protein PAX3-FKHR into the Pax3 locus. Rescue of the Pax3 mutant phenotypes by PAX3-FKHR suggests that Pax3 acts as a transcriptional activator during embryogenesis. This is confirmed by a Pax… CONTINUE READING
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