The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

@article{Webster1989TheTA,
  title={The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.},
  author={Nicholas J. G. Webster and Stephen Green and Diane Tasset and M Ponglikitmongkol and Pierre Chambon},
  journal={The EMBO journal},
  year={1989},
  volume={8 5},
  pages={1441-6}
}
Using GAL4 chimeric receptors, we have reported previously that the hormone-binding domain (HBD) of the human oestrogen receptor (hER) contains an hormone-inducible transcription activation function. We have extended that study here to show that this activation function represents the major activating domain in the hER in HeLa cells. In addition, we have expressed the various exons encoding the hER HBD as GAL4 fusion proteins and have shown that none contain a discrete activation function. Thus… CONTINUE READING