The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems.

@article{TalSinger1999TheTA,
  title={The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems.},
  author={Ruth Tal-Singer and Rath Pichyangkura and Eunsook Chung and Todd M Lasner and B P Randazzo and John Q. Trojanowski and Nigel W. Fraser and Steven J. Triezenberg},
  journal={Virology},
  year={1999},
  volume={259 1},
  pages={20-33}
}
The herpes simplex virus (HSV) transactivator VP16 is a structural component of the virion that activates immediate-early viral gene expression. The HSV-1 mutant in1814, which contains a 12-bp insertion that compromises the transcriptional function of VP16, replicated to a low level if at all in the trigeminal ganglia of mice (I. Steiner, J. G. Spivack, S. L. Deshmane, C. I. Ace, C. M. Preston, and N. W. Fraser (1990). J. Virol. 64, 1630-1638; Valyi-Nagy et al., unpublished data). However… CONTINUE READING

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