The transcription-repression domain of the adenovirus E1A oncoprotein targets p300 at the promoter

@article{Green2008TheTD,
  title={The transcription-repression domain of the adenovirus E1A oncoprotein targets p300 at the promoter},
  author={M. Green and N. Panesar and P. Loewenstein},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={4446-4455}
}
Extensive mutational/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino acids of the adenovirus E1A 243R oncoprotein suggests a model for the molecular mechanism of E1A repression: E1A accesses transcriptional co-activators such as p300 on specific promoters and then interacts with TBP to disrupt the TBP–TATA complex. In support of this model, as reported here, a basal core promoter activated by tethering p300 is repressible by E1A at the promoter… Expand
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein
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