The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.

@article{Wang2014TheTF,
  title={The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.},
  author={Yan Wang and Jernej Godec and Khadija Ben-Aissa and Kairong Cui and Keji Zhao and Alexandra B Pucsek and Yun Kyung Lee and Casey T Weaver and Ryoji Yagi and Vanja Lazarevic},
  journal={Immunity},
  year={2014},
  volume={40 3},
  pages={355-66}
}
T helper 17 (Th17) cells can give rise to interleukin-17A (IL-17A)- and interferon (IFN)-γ-double-producing cells that are implicated in development of autoimmune diseases. However, the molecular mechanisms that govern generation of IFN-γ-producing Th17 cells are unclear. We found that coexpression of the Th1 and Th17 cell master transcription factors, T-bet and retinoid-related orphan receptor gamma-t (RORγt), respectively, did not generate Th cells with robust IL-17 and IFN-γ expression… CONTINUE READING