The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development.

@article{Andrews2001TheTF,
  title={The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development.},
  author={G. K. Andrews and Dug Keun Lee and Rudravajhala Ravindra and Peter Lichtlen and Mario Sirito and Mich{\`e}le Sawadogo and Walter Schaffner},
  journal={The EMBO journal},
  year={2001},
  volume={20 5},
  pages={1114-22}
}
During early development of the mouse embryo, expression of the metallothionein-I (MT-I) gene is heightened specifically in the endoderm cells of the visceral yolk sac. The mechanisms of regulation of this cell-specific pattern of expression of metallothionein-I are unknown. However, it has recently been shown that MTF-1, functioning as a metalloregulatory transcription factor, activates metallothionein genes in response to the essential metal zinc. In contrast with the metallothionein genes… CONTINUE READING

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