The transcription factor snail regulates osteogenic differentiation by repressing Runx2 expression.

@article{Park2010TheTF,
  title={The transcription factor snail regulates osteogenic differentiation by repressing Runx2 expression.},
  author={Su Jin Park and Seung-Hyun Jung and Gadi Jogeswar and Hyun-Mo Ryoo and Jong In Yook and Han Seok Choi and Yumie Rhee and Cheol-Hee Kim and S K Lim},
  journal={Bone},
  year={2010},
  volume={46 6},
  pages={1498-507}
}
Osteoblasts originate from mesenchymal stem cells by the coordinated activities of different signaling pathways that regulate the expression of osteoblast-specific genes. Runt-related transcription factor 2 (Runx2) is the master transcription factor for osteoblast differentiation. Despite the importance of Runx2 in the developing skeleton, how Runx2 expression is regulated remains a pivotal question. Snail, a zinc finger transcription factor, is essential for triggering epithelial-to… CONTINUE READING
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