The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha.

@article{Dhasarathy2007TheTF,
  title={The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha.},
  author={Archana Dhasarathy and Masahiro Kajita and Paul A Wade},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 12},
  pages={2907-18}
}
The estrogen receptor (ER)-alpha (ESR1) is a key regulatory molecule in mammary epithelial cell development. Loss of ER-alpha in breast cancer is correlated with poor prognosis, increased recurrence after treatment, and an elevated incidence of metastasis. A proposed molecular pathway by which ER-alpha acts to constrain invasive growth in breast cancer cells involves direct, ER-alpha-dependent expression of metastasis-associated protein 3, a cell-type-specific component of the Mi-2/NuRD… CONTINUE READING

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