The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction.

@article{Stern2013TheTF,
  title={The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction.},
  author={Sina Stern and Stephanie Haverkamp and Daniela Sinske and Andrea Tedeschi and Ulrike Naumann and Simone Di Giovanni and Stefan Kochanek and Alfred Nordheim and Bernd Kn{\"o}ll},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 48},
  pages={18836-48}
}
Axonal injury generates growth inert retraction bulbs with dynamic cytoskeletal properties that are severely compromised. Conversion of "frozen" retraction bulbs into actively progressing growth cones is a major aim in axon regeneration. Here we report that murine serum response factor (SRF), a gene regulator linked to the actin cytoskeleton, modulates growth cone actin dynamics during axon regeneration. In regeneration-competent facial motoneurons, Srf deletion inhibited axonal regeneration… CONTINUE READING
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