The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling.

@article{Du2013TheTF,
  title={The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-β (TGFβ) signaling.},
  author={Baowen Du and William P Cawthorn and Alison Su and Casey R. Doucette and Yao Yao and Nahid Hemati and Sarah E Kampert and Colin S McCoin and David T Broome and Clifford J. Rosen and Gong She Yang and Ormond A Macdougald},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 5},
  pages={3036-47}
}
Differentiation of adipocytes from preadipocytes contributes to adipose tissue expansion in obesity. Impaired adipogenesis may underlie the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mechanistically, a well defined transcriptional network coordinates adipocyte differentiation. The family of paired-related homeobox transcription factors, which includes Prrx1a, Prrx1b, and Prrx2, is implicated with regulation of mesenchymal cell fate, including myogenesis… CONTINUE READING
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