The transcription factor p53: Not a repressor, solely an activator

@article{Fischer2014TheTF,
  title={The transcription factor p53: Not a repressor, solely an activator},
  author={M. Fischer and L. Steiner and K. Engeland},
  journal={Cell Cycle},
  year={2014},
  volume={13},
  pages={3037 - 3058}
}
  • M. Fischer, L. Steiner, K. Engeland
  • Published 2014
  • Biology, Medicine
  • Cell Cycle
  • The predominant function of the tumor suppressor p53 is transcriptional regulation. It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional repression have been postulated. Here, we evaluate these models based on a computational meta-analysis of genome-wide data. Surprisingly, several major models of p53-dependent gene regulation are… CONTINUE READING
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