The transcription factor p53: Not a repressor, solely an activator

@inproceedings{Fischer2014TheTF,
  title={The transcription factor p53: Not a repressor, solely an activator},
  author={Martin Fischer and Lydia Steiner and Kurt Engeland},
  booktitle={Cell cycle},
  year={2014}
}
The predominant function of the tumor suppressor p53 is transcriptional regulation. It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional repression have been postulated. Here, we evaluate these models based on a computational meta-analysis of genome-wide data. Surprisingly, several major models of p53-dependent gene regulation are… CONTINUE READING

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