The transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative promoter.

@article{Hao2011TheTF,
  title={The transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative promoter.},
  author={Hong Xing Hao and Padmaja Tummala and Eduardo Guzm{\'a}n and Raghuveer Singh Mali and Janina Gregorski and Anand Swaroop and Kenneth P. Mitton},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 40},
  pages={34893-902}
}
Neural retina leucine zipper (NRL) is an essential transcription factor for cell fate specification and functional maintenance of rod photoreceptors in the mammalian retina. In the Nrl(-/-) mouse retina, photoreceptor precursors fail to produce rods and generate functional cone photoreceptors that predominantly express S-opsin. Previous global expression analysis using microarrays revealed dramatically reduced expression of myocyte enhancer factor Mef2c in the adult Nrl(-/-) retina. We… CONTINUE READING
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