The transcription factor Wilms tumor 1 regulates matrix metalloproteinase-9 through a nitric oxide-mediated pathway.

@article{MarcetPalacios2007TheTF,
  title={The transcription factor Wilms tumor 1 regulates matrix metalloproteinase-9 through a nitric oxide-mediated pathway.},
  author={Marcelo Marcet-Palacios and Marina Ulanova and Florentina Duta and Lakshmi Puttagunta and Samira Mu{\~n}oz and Derrick Gibbings and Marek Radomski and Lisa Cameron and Irvin Mayers and A Dean Befus},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={256-65}
}
Matrix metalloproteinase-9 (MMP-9) is released by human lung epithelial cells (LEC) in conditions such as asthma and chronic obstructive pulmonary disease and expression of MMP-9 correlates with the severity of these disorders. MMP-9 production has been reported to be regulated by a NO/soluble guanylate cyclase-dependent pathway. Transcriptional regulation of this enzyme, however, is poorly understood. Using phylogenetic analysis, we observed a highly conserved sequence in the 5' flanking… CONTINUE READING