The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability

@article{Jeub2011TheTF,
  title={The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability},
  author={Monika Jeub and Michael Emrich and Bruno Pradier and Omneya Taha and Ildik{\'o} R{\'a}cz},
  journal={PAIN®},
  year={2011},
  volume={152},
  pages={2384-2398}
}
The perception of pain is initiated by the transduction of noxious stimuli through specialized ion channels and receptors expressed by primary nociceptive neurons. The molecular mechanisms that orchestrate the expression and function of ion channels relevant for pain processing are poorly understood. We demonstrate here a central role of the transcription factor Smad-interacting protein 1 (Sip1/Zfhx1b/Zeb2), a 2-handed zinc finger DNA-binding protein with essential functions in neural crest and… CONTINUE READING

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