The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.

@article{Lee2012TheTF,
  title={The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7.},
  author={Jee Won Lee and Hye Seon Kang and Jae Youn Lee and Eun Jung Lee and Hyewhon Rhim and Joo Heon Yoon and Su Ryeon Seo and Kwang Chul Chung},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={420 2},
  pages={
          404-10
        }
}
  • Jee Won Lee, Hye Seon Kang, +5 authors Kwang Chul Chung
  • Published 2012
  • Biology, Medicine
  • Biochemical and biophysical research communications
Down syndrome is the most common genetic disorder and is characterized by three copies of chromosome 21. Regulator of calcineurin 1 (RCAN1) is located close to the Down syndrome critical region (distal part of chromosome 21), and its product functions as an endogenous inhibitor of calcineurin signaling. RCAN1 protein stability is regulated by several inflammatory signaling factors, though the underlying mechanisms remain incompletely understood. Here, we report that RCAN1 interacts with the… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone‐mediated autophagy and ubiquitin proteasome pathways
TLDR
In addition to being degraded through the ubiquitin proteasome pathway, it was found that lysosomal inhibition markedly increased RCAN1 protein expression in a time‐ and dosage‐dependent manner, indicating that RCAN 1 degradation is not through a macroautophagy pathway. Expand
Nedd4-2 ubiquitin ligase interacts with RCAN1 (DSCR1) for the proteasomal degradation
TLDR
The data provide the first evidence that Nedd4-2 acts as an important regulatory component in the control of RCAN1 protein stability. Expand
The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin
TLDR
It is shown that phosphorylation of yeast RCN, Rcn1, triggers degradation through the SCFCdc4 ubiquitin ligase complex, which provides insight into the mechanism involved in maintaining proper responses to Ca2+ signals. Expand
NF-κB-inducing Kinase Phosphorylates and Blocks the Degradation of Down Syndrome Candidate Region 1*
TLDR
It is demonstrated that NIK specifically interacts with and phosphorylates the C-terminal region of DSCR1 in immortalized hippocampal cells as well as in primary cortical neurons, and an increase in insoluble D SCR1 levels results in the formation of cytosolic aggregates. Expand
Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.
TLDR
Results suggest that H2O2 induces SCF beta-TrCP-mediated ubiquitination of RCAN1, leading to a decrease in the protein level of RC AN1. Expand
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
TLDR
A new role for TGIF as a component of a ubiquitin ligase complex that mediates the degradation of Smad2 in response to TGF‐β signaling is revealed. Expand
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α
TLDR
This work shows that p300 and/or CBP (CREB-binding protein), which are transcription adaptors targeted by E1A, interact specifically with Stat2, and finds that this domain of Stat2 has transactivation potential, which correlates with its binding to p300/CBP, which provides a new mechanism for inhibition of the IFN-α-activated antiviral response by E 1A. Expand
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs.
TLDR
It is shown that the stimulatory effect of yeast Rcn1 involves phosphorylation of a conserved serine residue by Mck1, a member of the GSK-3 family of protein kinases, which may contribute to a positive feedback loop involving calcineurin-dependent up-regulation of RCN expression. Expand
CREB activates proteasomal degradation of DSCR1/RCAN1
  • Su Ryeon Seo, Kwang Chul Chung
  • Chemistry, Medicine
  • FEBS letters
  • 2008
TLDR
The results reveal a new regulatory role for CREB in DS pathology through the proteasomal degradation of RCAN1 through the ubiquitin‐proteasome pathway. Expand
Role of STAT2 in the alpha interferon signaling pathway
TLDR
U6A, a mutant cell line which lacks the STAT2 subunit of the transcription factor interferon (IFN)-stimulated gene factor 3 (ISGF3), is isolated and implementation of U6A cells with a cDNA encoding STAT2 restores the IFN-alpha response, proving that STAT2 is required in this pathway. Expand
...
1
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3
4
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