The transcription factor RBP-J is essential for retinal cell differentiation and lamination

@inproceedings{Zheng2009TheTF,
  title={The transcription factor RBP-J is essential for retinal cell differentiation and lamination},
  author={Minhua Zheng and Ming Shi and Zhe Pei and Fang Gao and Hua Han and Yu-Qiang Ding},
  booktitle={Molecular Brain},
  year={2009}
}
The highly ordered vertebrate retina is composed of seven cell types derived from a common pool of retinal progenitor cells (RPCs), and is a good model for the studies of cell differentiation and interaction during neural development. Notch signaling plays a pivotal role in retinogenesis in mammals, but the full scope of the functions of Notch pathway, and the underlying molecular mechanisms, remain unclear. In this study, we conditionally knocked out RBP-J, the critical transcription factor… CONTINUE READING