The transcription factor PU.1 is involved in macrophage proliferation

  title={The transcription factor PU.1 is involved in macrophage proliferation},
  author={Antonio Celada and Francesc Enric Borr{\`a}s and Concepci{\'o} Soler and Jorge Lloberas and Michael J. Klemsz and Charles Van Beveren and Scott McKercher and Richard A Maki},
  journal={The Journal of Experimental Medicine},
  pages={61 - 69}
PU.1 is a tissue-specific transcription factor that is expressed in cells of the hematopoietic lineage including macrophages, granulocytes, and B lymphocytes. Bone marrow-derived macrophages transfected with an antisense PU.1 expression construct or treated with antisense oligonucleotides showed a decrease in proliferation compared with controls. In contrast, bone marrow macrophages transfected with a sense PU.1 expression construct displayed enhanced macrophage colony-stimulating factor (M-CSF… CONTINUE READING


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Comparison of the expression of transcription factor PU.1 between murine macrophages and B lymphocytes. Oncogene

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  • Celada et al. on F ebuary 23,
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