The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells.

Abstract

Interactions with antigen-presenting cells (APCs) interrupt T cell migration through tissues and trigger signaling pathways that converge on the activation of transcriptional regulators, including nuclear factor of activated T cells (NFAT), which control T cell function and differentiation. Both stable and unstable modes of cognate T cell-APC interactions… (More)
DOI: 10.1016/j.immuni.2012.09.012

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