The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance.

@article{Mayo2000TheTF,
  title={The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance.},
  author={Marty W. Mayo and Albert S Baldwin},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1470 2},
  pages={M55-62}
}
Discovered in 1986 as a DNA binding activity that recognized the immunoglobulin light chain intronic enhancer, NF-kappaB has been studied intensively for its role in controlling expression of genes involved in immune and inflammatory function. However, more recently, NF-kappaB has been implicated in controlling cell growth and oncogenesis. The link between NF-kappaB and cancer stems, in part, from the fact that this transcription factor is capable of inducing gene products that control… CONTINUE READING

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