The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation.

@article{Mayo2009TheTF,
  title={The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation.},
  author={Jaime L. Mayo and Devin N. Holden and Jeffery R. Barrow and Laura C Bridgewater},
  journal={Experimental cell research},
  year={2009},
  volume={315 13},
  pages={
          2293-300
        }
}
The transcription factor Lc-Maf, which is a splice variant of c-Maf, is expressed in cartilage undergoing endochondral ossification and participates in the regulation of type II collagen through a cartilage-specific Col2a1 enhancer element. Type XXVII and type XI collagens are also expressed in cartilage during endochondral ossification, and so enhancer/reporter assays were used to determine whether Lc-Maf could regulate cartilage-specific enhancers from the Col27a1 and Col11a2 genes. The… CONTINUE READING
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