The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.

@article{Marrone2013TheTF,
  title={The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins.},
  author={Giusi Marrone and Lucia Russo and Eugenio Rosado and Diana Hide and Guillermo Garc{\'i}a-Carde{\~n}a and Juan C Garc{\'i}a-Pag{\'a}n and J Bosch and Jorge Gracia-Sancho},
  journal={Journal of hepatology},
  year={2013},
  volume={58 1},
  pages={98-103}
}
BACKGROUND & AIMS Statins improve hepatic endothelial function and liver fibrosis in experimental models of cirrhosis, thus they have been proposed as therapeutic options to ameliorate portal hypertension syndrome. The transcription factor Kruppel-like factor 2 (KLF2) may be induced by statins in liver sinusoidal endothelial cells (SEC), orchestrating an efficient vasoprotective response. The present study aimed at characterizing whether KLF2 mediates statins-derived hepatic protection… CONTINUE READING
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