The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis.

@article{Palumbo2011TheTF,
  title={The transcription factor JunD mediates transforming growth factor \{beta\}-induced fibroblast activation and fibrosis in systemic sclerosis.},
  author={Katrin Palumbo and Pawel Zerr and Michal Tom{\vc}{\'i}k and Stefan Vollath and Clara Dees and Alfiya Akhmetshina and J{\'e}r{\^o}me Avouac and M. Yaniv and Oliver Distler and Georg Schett and Joerg H. W. Distler},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 7},
  pages={1320-6}
}
OBJECTIVES Transforming growth factor β (TGFβ) has been identified as a key player in fibrotic diseases. However, the molecular mechanisms by which TGFβ activates fibroblasts are incompletely understood. Here, the role of JunD, a member of the activator protein 1 (AP-1) family of transcription factors, as a downstream mediator of TGFβ signalling in systemic sclerosis (SSc), was investigated. METHODS The expression of JunD was analysed by real-time PCR, immunofluorescence, western blotting and… CONTINUE READING

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