The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.

@article{Liang2001TheTF,
  title={The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.},
  author={Qiangrong Liang and Russell J. Wiese and Orlando Francisco Amode Bueno and Yusheng Dai and Bruce E. Markham and Jeffery D Molkentin},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 21},
  pages={
          7460-9
        }
}
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate that GATA4 is itself regulated by the mitogen-activated protein kinase signaling cascade through direct phosphorylation. Site-directed mutagenesis and phospho-specific GATA4 antiserum revealed serine 105 as the primary site involved in agonist-induced… CONTINUE READING
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