The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

@inproceedings{Georges2014TheTF,
  title={The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells},
  author={Adrien Georges and David L'h{\^o}te and Anne Laure Todeschini and Aur{\'e}lie Auguste and B{\'e}rang{\`e}re Legois and Alain Zider and Reiner A. Veitia},
  booktitle={eLife},
  year={2014}
}
FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells. We found that FOXL2 is required for normal gene regulation by steroid receptors, and we show that estrogen receptor beta (ESR2) is the main vector of estradiol signaling in these cells. Moreover, we found that FOXL2 directly modulates Esr2 expression… CONTINUE READING
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