The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

@article{Loughran2008TheTF,
  title={The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells},
  author={Stephen J Loughran and Elizabeth A. Kruse and Douglas F. Hacking and Carolyn A. de Graaf and Craig D. Hyland and Tracy A Willson and Katya J. Henley and Sarah Ellis and Anne Kathrin Voss and Donald Metcalf and Douglas J. Hilton and Warren S. Alexander and Benjamin T Kile},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={810-819}
}
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that… CONTINUE READING
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