The transcription factor Engrailed-2 guides retinal axons

@article{Brunet2005TheTF,
  title={The transcription factor Engrailed-2 guides retinal axons},
  author={Isabelle Brunet and Christine Weinl and Michael Piper and Alain Trembleau and Michel Volovitch and William G. Harris and Alain Prochiantz and Christine E Holt},
  journal={Nature},
  year={2005},
  volume={438},
  pages={94-98}
}
Engrailed-2 (En-2), a homeodomain transcription factor, is expressed in a caudal-to-rostral gradient in the developing midbrain, where it has an instructive role in patterning the optic tectum—the target of topographic retinal input. In addition to its well-known role in regulating gene expression through its DNA-binding domain, En-2 may also have a role in cell–cell communication, as suggested by the presence of other domains involved in nuclear export, secretion and internalization… CONTINUE READING

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