The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.

@article{Rodier2015TheTF,
  title={The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.},
  author={Genevi{\`e}ve Rodier and Olivier Kirsh and Martin Andres Baraibar and Thibault C Houles and Matthieu Lacroix and H{\'e}l{\`e}ne Delpech and Elodie Hatchi and St{\'e}phanie Arnould and D. Severac and Emeric Dubois and Julie Caramel and Eric Julien and Bertrand Friguet and Laurent Le Cam and Claude Sardet},
  journal={Cell reports},
  year={2015},
  volume={11 2},
  pages={220-33}
}
Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cycle. Here, we show that another factor, the multifunctional protein E4F1, directly controls genes involved in mitochondria functions and cell-cycle checkpoints, including Chek1, a major component of the DNA damage response. Coordination of these cellular functions by E4F1 appears… CONTINUE READING
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