The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells


The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (TH2) cells but also by TH1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic TH1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically… (More)
DOI: 10.1038/ni.2020


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