The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation.

@article{Hou2001TheTF,
  title={The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation.},
  author={Sheng Tao Hou and E. Baron John J. Cowan and Teena Walker and Nguyen Fiong Ohan and Mike Dove and I Rasqinha and J. P. Macmanus},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 2},
  pages={287-97}
}
The E2F1 transcription factor plays an important role in promoting neuronal apoptosis; however, it is not clear how E2F1 does this. Here we show that E2F1 is involved in dopamine (DA)-evoked apoptosis in cerebellar granule neurons (CGNs). E2F1 -/- CGNs and CGNs expressing an antisense E2F1 cDNA were significantly protected from DA-toxicity relative to controls. The neuronal protection was accompanied by significantly reduced caspase 3 activity. E2F1-mediated neuronal apoptosis did not require… CONTINUE READING

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