The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.

@article{Anderson2011TheTE,
  title={The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively.},
  author={Susan J. Anderson and Martha L. Sikes and Yinfeng Zhang and Sarah L. French and Shilpa R Salgia and A. L. Beyer and Masayasu Nomura and David Andrew Schneider},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 21},
  pages={18816-24}
}
Spt5p is a universally conserved transcription factor that plays multiple roles in eukaryotic transcription elongation. Spt5p forms a heterodimer with Spt4p and collaborates with other transcription factors to pause or promote RNA polymerase II transcription elongation. We have shown previously that Spt4p and Spt5p also influence synthesis of ribosomal RNA by RNA polymerase (Pol) I; however, previous studies only characterized defects in Pol I transcription induced by deletion of SPT4. Here we… CONTINUE READING

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