The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.

@article{Besmer2006TheTE,
  title={The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.},
  author={Eva Besmer and Eleonora Market and F Nina Papavasiliou},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 11},
  pages={4378-85}
}
Activation-induced cytidine deaminase (AID) is a single-stranded DNA deaminase required for somatic hypermutation of immunoglobulin (Ig) genes, a key process in the development of adaptive immunity. Transcription provides a single-stranded DNA substrate for AID, both in vivo and in vitro. We present here an assay which can faithfully replicate all of the molecular features of the initiation of hypermutation of Ig genes in vivo. In this assay, which detects AID-mediated deamination in the… CONTINUE READING

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