The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct.

@article{Lin1997TheTA,
  title={The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct.},
  author={Yihui Lin and Takahiro Nomura and Toshiharu Yamashita and Dorjbal Dorjsuren and Hong Tang and Seishi Murakami},
  journal={Cancer research},
  year={1997},
  volume={57 22},
  pages={5137-42}
}
Transactivation of viral and host genes expression by hepatitis B virus X protein (HBx) is believed to be involved in hepatocarcinogenesis. The interaction of HBx with the tumor suppressor p53 and its inhibitory effect on p53 functions have been reported recently. However, the question of whether p53 is directly involved in HBx transactivation has not yet been addressed. In this study, we delineated the interaction sites of HBx and p53 using far-Western blotting and glutathione S-transferase… CONTINUE READING
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