The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.

@article{Schauwienold2008TheTE,
  title={The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.},
  author={Dag Schauwienold and Alejandra P{\'e}rez Sastre and Nadine Genzel and Michael Schaefer and Hans Peter Reusch},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 41},
  pages={27748-56}
}
G protein-coupled receptors such as proteinase-activated receptor 1 induce phosphorylation of mitogen-activated protein kinases through multiple pathways including transactivation of receptor tyrosine kinases. In vascular smooth muscle cells, both matrix-metalloproteinase-dependent extracellular shedding of membrane-bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases Pyk2 and Src contributed to the thrombin-induced ERK1/2 phosphorylation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.

EGF Receptor Recruits Pyk2 to Regulate Src 27756 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • S. Eguchi, P. J. Dempsey, G. D. Frank, E. D. Motley, T. Inagami
  • J. Biol. Chem
  • 2001

Similar Papers

Loading similar papers…