The trans-activator gene of HTLV-III is essential for virus replication

@article{Fisher1986TheTG,
  title={The trans-activator gene of HTLV-III is essential for virus replication},
  author={A. Fisher and M. Feinberg and S. Josephs and M. Harper and L. Marselle and G. Reyes and M. Gonda and A. Aldovini and Christine Debouk and R. Gallo and F. Wong-Staal},
  journal={Nature},
  year={1986},
  volume={320},
  pages={367-371}
}
Studies of the genomic structure of human T-lymphotropic virus type III (HTLV-III) and related viruses, implicated as the causal agent of acquired immune deficiency syndrome (AIDS), have identified a sixth open reading frame in addition to the five previously known within the genome (gag, pol, sor, env and 3′orf)1–4. This gene, called tat-III, lies between the sorand env genes and is able to mediate activation, in a trans configuration, of the genes linked to HTLV-III long terminal repeat (LTR… Expand
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