The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.

@article{Alroy2005TheTN,
  title={The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.},
  author={Iris Alroy and Shmuel Tuvia and Tsvika Greener and Daphna Gordon and Haim M. Barr and Daniel Taglicht and Revital Mandil-Levin and Danny Ben-Avraham and Dalit Konforty and Anat Nir and Orit Levius and Vivian Bicoviski and Mally Dori and Shenhav Cohen and Liora Yaar and Omri Erez and Oshrat Propheta-Meiran and Mordechai Koskas and Elanite Caspi-Bachar and Iris Alchanati and Alin Sela-Brown and Haim Moskowitz and Uwe Tessmer and Ulrich Schubert and Yuval Reiss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 5},
  pages={1478-83}
}
HIV type 1 (HIV-1) was shown to assemble either at the plasma membrane or in the membrane of late endosomes. Now, we report an essential role for human ubiquitin ligase POSH (Plenty of SH3s; hPOSH), a trans-Golgi network-associated protein, in the targeting of HIV-1 to the plasma membrane. Small inhibitory RNA-mediated silencing of hPOSH ablates virus… CONTINUE READING